Triple Action Antifungal Topic

Today we are witnessing the development and marketing of triple action antifungals for the treatment of superficial mycoses. It is a mixture of antifungals, antibiotics, and anti-inflammatories. It is a combination of antifungals with conventional non-antifungal agents reoriented for their action on the growth of fungi. They consist of antibacterial drugs and steroidal anti-inflammatory drugs. This reorientation has, however, unexpected effects. Indeed, the presence of the antibiotic acts on reducing the composition of the colonizing microbiota which promotes fungal growth and indirectly improves fungal pathogenicity, and the corticosteroid component may interfere with the therapeutic actions of the antifungal agent and may accelerate growth. fungal, due to a decrease in the local immunological of the host, so that the underlying infection may persist, and the dermatophytes may even acquire the ability to invade deeper tissues. Thus, for optimal antifungal therapy, it would be interesting to favor antifungals without combinations than those combining antibiotics and anti-inflammatories which, in addition to the facts in this book, have an extremely high rate of recurrence.